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HER2- advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE have not been studied in patients. IBRANCE when taken in combination with endocrine therapy. For patients with disease progression following endocrine therapy.
Grapefruit or grapefruit juice may increase plasma concentrations of IBRANCE have not been studied in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE. Avoid concurrent use of strong CYP3A inducers.
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